423 M1490 Advanced Medicinal Chemistry II (高等藥物化學 (二))必修
Prerequisites: M1470
Terms: Spring
Credits: 3
Format: Lecture
Instructors: J.-W. Chern, L.-W. Hsin, J.-H. Lin, C.-J. Lin, F.-L. Kung, and J.-H. Guh

Course Description: This is the second part of a one-year survey course aimed to introduce first-year medicinal chemistry graduate students to various aspects of drug design and development. Topics of this course include functional and structural studies of macromolecular targets, how the information obtained from these studies aids in drug design and development, and other methods used in pharmaceutical research. Students who are interested in a particular subject may elect a more advanced course in consultation with their advisor. Three hours of lecture per week.

Week Topic
Drugs Acting on Macromolecular Targets
1 Design of Enzyme Inhibitors (JWC)
2 Design of Enzyme Inhibitors (JWC)
3 DNA-Interactive Agents (LWH)
4 DNA-Interactive Agents (LWH-1 hour); Radiopharmaceuticals (LWH-2 hours)
Applying Informatics to Drug Development
5 Cheminformatics (LWH-2 hours); Bioinformatics (JHL);
6 Bioinformatics (JHL)
7 Genomics and Proteomics (FLK-2 hours); Bioassays (JHG-1 hour)
Bioactivity Evaluation
8 Bioassays (JHG)
9 Bioassays (JHG-2 hours); High-throughput Screening (JHG-1 hour)
10 High-throughput Screening (JHG)
11 Microarray for New Drug Discovery (FLK or others-2 hours); Combinatorial Chemistry and Parallel Synthesis (LWH-1 hour)
12 Combinatorial Chemistry and Parallel Synthesis (LWH)
13 Basic Equations of Enzyme Kinetics (FLK-1 hours); Practical Kinetics (FLK-2 hour)
14 Enzyme Inhibition and Inactivation (FLK)
15 Pharmacokinetics (CJL)
16 Pharmacokinetics (CJL-1 hour); Metabolism (CJL-2 hours)
17 Metabolism (CJL-2 hours)

Schedule is subject to change